Hi everyone,

I was looking a breeder's website (not my breeder) but it stated that anyone who purchased a puppy from them would invalidate their health guarantee  warranty by giving their puppy nexguard, bravecto, comfortis  and any internal flea prevention.  I thought that was strange.  It stated due to reports regarding kidney and liver damage.  I haven't heard this before.  

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  • The breeder who owns Jasper's sire also has the same thing in her sales contract regarding Nexguard, Bravecto and and Simparica (not Comfortis). (And not the part about internal flea prevention, although she does strongly recommend spot-ons for flea/tick preventtion rather than oral meds.) 
    The FDA has issued several warnings about the active ingredient, isoxazoline, in these three preventatives causing neurological issues. Not liver and kidney issues.


    Comfortis is not included and it contains a different active ingredient, so not sure why this breeder chose to include that. I think this breeder means well in temrs of protecting her puppies but isn't understanding the FDA warning information. There was an FDA warning years ago about not giving Comfortis if you are giving ivermectin (Heartgard) because of possible drug interactions. 

    At any rate, IMO all pet owners would be well-advised to heed the FDA warning about Nexgard, Bravecto and Simparica. 

    • What should you give I wonder?  I have been giving my yorkie  Nexguard and she is on  Heartgard. She hates trifexis.

  • Wow Khloe goes for her annual next month. I am going to mention this.  Unfortunately we live in the South and deer love my back yard. Ticks are common here. I remember frontline  because I was using that back in the day when my bichon was a pup.  And when my daughter gets her doodle pup next month I am going to make sure she mentions this to the vet to get the best recommendations for the new baby.  Thanks Karen this forum has very useful information.

    • We liked Revolution for Luna - it is a bit more expensive than some of the others but application is easy and it has everything in one.  We do have ticks in our area and Luna never got any ticks even though we took her to a local wooded area (dog park/trail) frequently.  We will discuss it with the vet but will likely go that route again for Riley.

      • Thanks a lot. I am definitely switching and I will be informing my daughter as well.

  • Hi,

    Nala is on heartguard, but we use vectra 3D for fleas and ticks. It is an external application, once  a month. (I also heard negative things about internal meds) Anyone heard anything about Vectra 3D?  We also live among the wildlife here and have to use something.

    Chris & Nala 

  • I asked my vet a couple of weeks ago about NexGard, and she said that if my dogs have been using it without any reaction for a while, then they should be fine continuing. We also give them Sentinel. 

    • I'm curious as to why you're giving both? If the Sentinel is just for HW, why not give Heartgard instead of doubling up on the flea meds?

  • I was just looking at the vet medication website, and I see that Bravecto now has a topical medication. It's the same drug, fluralaner, and it is still supposed to be effective for 12 weeks. I think this is a new application, or I would have noticed. I'm curious if anyone has any insight to the pros and cons of the ingested vs. topical if it's the same drug. My understanding (which may be completely wrong) is that the topical is still systemic, ie it gets into their glands or something, and that's why they can have a bath and it doesn't wash off.

    I'm reasonably comfortable with the medications I've chosen. All drugs, no matter how benign are going to have an adverse effect for someone somewhere. But then every time I hear something new I worry again!

    • I deleted my answer and did a little research.
      Fluralaner, Afoxolaner, and Sarolaner are the isoxazolines in Bravecto, Nexgard and Simparica, respectively. 
      I don;t know if they are safer given topically than orally. The FDA warning does not make a distinction. Jeter's breeder also doesn't make the distinction. Agree not to use these products period or she won't sell you a puppy, lol. 

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